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doi: 10.1016/j.celrep.2015.06.034 13 GalsgaardKDPedersenJKnopFKHolstJJWewer AlbrechtsenNJ

In contrast, Linagliptin is a long-acting drug because of its high degree of binding to dipeptidyl peptidase-4 (DPP-4)

Shirsath N, Rathos M, Chaudhari U, Sivaramakrishnan H, Joshi K

32 GST in regulation of MAPK pathway Besides metabolite detoxification, GST also exhibits ligand-binding properties that allow the enzyme to interact covalently and noncovalently with compounds, resulting in inhibition of conjugation activity